Juve trailed 2-0 from the first clash in Spain but a Ronaldo hat-trick helped keep their hopes of a first European triumph since 1996 alive.
Two headers and an 86th-minute penalty saw Ronaldo net his fifth career treble against Atletico, having proved the scourge of Simeone and co. at Real Madrid before his switch to Juve.
Ronaldo – the Champions League’s all-time top scorer with 124 strikes – has now sent Atleti packing in all of the last five seasons in the competition, having helped beat them twice in finals with Madrid.
And after scoring his late spot-kick, Ronaldo seemingly took the opportunity to take a jab at Simeone.
The Argentine coach had celebrated emphatically during the first leg at the Wanda Metropolitano, grabbing his crotch with both hands.
He later explained the celebration as praising the fact his side “have balls” and showed “a lot of balls” in their first-leg win but was handed a €20,000 for the provocative nature of the gesture.
Someone acknowledged: “It’s not a nice gesture I admit, but I felt the need to do it. I did it as a player at Lazio. I can only apologise if anyone was offended.”
Ronaldo repeated a similar gesture, thrusting forward several times as he mimicked Simeone.
The Portuguese talisman’s eighth hat-trick in this competition helped maintain the club’s hopes of a first Champions League triumph since 1996.
Ronaldo’s £88million switch from holders Real to Juve, it is thought, was largely motivated by the Old Lady’s desperation for success on the continent.
Juve have lost five finals since their last success against Borussia Dortmund, including to Ronaldo and Real in 2017.
But as a five-time champion, Ronaldo is hoping to become the second player ever after Clarence Seedorf to lift the trophy with three different clubs having also been triumphant with Manchester United earlier in his career.
And the prolific 34-year-old Sky Sport Italia: “It had to be a really special night and it was.
“If we continue like this, we have not won yet but we have reasons to be proud and we are on the right way.
“That’s why Juve signed me and I tried to do my best job.
“It’s a magical night. It was a very difficult team to play but we showed that we were a very big team.
“We proceed step by step, we will see.”
Juve will find out their quarter-final opponents in Friday’s draw. Ronaldo will not be handed a return to Madrid after Real crashed out to Ajax.