The Blues boss has been reluctant to use Hudson-Odoi in the league this season, preferring to deploy the 18-year-old in cup competitions.
However, a hectic run of fixtures means Sarri has been forced to utilise the promising winger in order to keep the rest of his squad fresh.
Chelsea fans have been vocal in their support of Hudson-Odoi this season, despite the youngster coming close to joining Bayern Munich in January, and the Blues faithful will be delighted to see him set for his first Premier League start.
Manager Sarri was spotted keeping a close eye on Hudson-Odoi as his side trained on Tuesday in preparation for the visit of Brighton to Stamford Bridge.
Speaking in his pre-match press conference yesterday, Sarri said: “In my opinion, he is our future.
“He will probably start tomorrow or in the next match.
“I realised in pre-season that Callum was a player with very great potential.
“But at that moment, he wasn’t ready to play at this level. During this season he has improved and now he’s ready to play.”
Hudson-Odoi made his full England debut against Montenegro during the recent international break, further highlighting the bizarre decision of Sarri’s not to select the winger.
Eight appearances off the bench in the Premier League this season is a meagre return considering Hudson-Odoi’s impressive displays in the Europa League, scoring four goals and providing two assists.
The promising talent is expected to line up on the opposite flank to Eden Hazard, who started on the bench last time out in a contentious win over Cardiff.
Hazard was photographed tearing around the training pitch at Cobham, with the Belgian joined by Gonzalo Higuain, Olivier Giroud and Pedro.
Frenchman Giroud will hope to start against the Seagulls after Higuain failed to fire in Wales.
Ruben Loftus-Cheek was also spotted working hard, with the midfielder likely to start alongside Jorginho and N’Golo Kante if Ross Barkley and Mateo Kovacic drop out.
Meanwhile, Andreas Christensen could come into the stating XI if David Luiz or Antonio Rudiger are rotated.
Danny Drinkwater was seen taking part in drills but is highly unlikely to feature, having not played a single minute of action under Sarri.