That is the view of former Manchester United chairman Martin Edwards, who can see a north-west rumble on the horizon.
Manchester United host Barcelona tonight in the first leg of their Champions League quarter-final.
Liverpool beat Porto 2-0 last night in their opening tie and are now favourites to progress.
Should the two English sides win their ties they will meet in the semi-finals later this month.
And Edwards – who was in charge at Old Trafford for 22 years until retiring in 2002 – reckons that is the ding dong fans want to see.
“We would find them against us if we reach the semi-finals.
“And it would be as historic a match as any in the Champions League.”
United and Liverpool almost met in the Champions League back in 2008 – but Chelsea knocked the Reds out of the competition at the semi-final stage to set up a final date with United in Moscow.
This year Manchester City and Barcelona appear the favourites to win the trophy.
But Edwards reckons Juventus cannot be discounted.
“Not only Barca and City, also Juventus have their chance,” he said.
“They have improved with (Cristiano) Ronaldo, of course, but they have already reached two finals recently and against Barcelona in 2015 were on the top, before Messi really made the difference.
“He changed the match (that day), but they were two teams at the same level.”