Lomachenko is one of the most formidable fighters in the world and is expected to win comfortably when the two meet in the early hours of Saturday morning.
Crolla last fought back in November against Daud Yordan in a close unanimous decision win.
A win for Lomachenko would likely see him pushed into potential bouts with the likes of Gervonta Davis and Teofimo Lopez in the near future.
A win for Mancunian Crolla would be one of the biggest upsets in boxing history.
Ahead of their bout in the states, both men have spoken about each other’s strengths and weaknesses.
“[Crolla] has very big experience, he has very good defence,” Lomachenko said.
“For me, I always focus very seriously for all my opponents, so he’s very dangerous, so I’m focusing.
“I just need to show my best style and ‘Style Loma’, that’s it.”
Crolla, on the other hand, is hoping to produce the upset of all upsets when they meet in L.A.
“I want to shock the World and beating him would be one of the biggest upsets of all time. But Lomachenko is mentally very tough, he makes fighters quit, I know that,” he said.
“I know I will have to put up with being frustrated by him.”
When is Lomachenko vs Crolla?
The fight takes place in the early hours of Saturday (April 13) morning.
Ring walks can be expected around 4am at Staples Centre in Los Angeles.
How can I watch?
The fight will be shown live on Sky Sports Action and Main Event and will be free to watch.