Wales centre Jonathan Davies is set to miss the 2018 Six Nations after being ruled out for “in the region of six months” with a foot injury.
The 29-year-old British and Irish Lions back was injured in the closing stages of Saturday’s 29-21 loss to Australia.
Scarlets’ Davies, who has played 65 times for Wales, needs surgery and may miss the rest of the season.
Harlequins centre Jamie Roberts has been added to Wales’ autumn Test squad, along with prop Scott Andrews.
And Wales hope scrum-half Rhys Webb and flanker Justin Tipuric will be fit for Saturday’s match against Georgia in Cardiff (14:30 GMT).
With Scarlets prop Samson Lee, who missed the defeat by Australia with an Achilles injury, still being monitored, Andrews is training with the squad.
Wing Steff Evans, a team-mate of Davies at Scarlets, was replaced in the second half against the Wallabies by Hallam Amos after scoring Wales’ first try.
In the immediate aftermath of the game, Wales coach Warren Gatland said: “He’s fine, he’s just got a knock on the knee.
“It wasn’t an injury replacement.
“He’s run himself into the ground and taken a couple of big hits.
“We felt it was about the right time to make a change.”