There have been reports of a significant explosion, according to local reports.
It comes immediately after Syrian state TV confirmed an airstrike hit had hit several bases.
Syria state television has confirmed its air defences are repelling attacks in the country’s Homs region.
The military announced at around 1.10am local time (11.10pm GMT) that it had fired missiles towards the Shay’rat Airbase, to the south-east of Homs, and its surrounding area in the Homs Governorate.
Several reporters in the area claim the airstrike was carried out by Israeli fighter jets flying at high altitude after crossing the borders through Lebanon.
There were also reports of covert airstrikes carried out by Israeli forces at Iranian bases in the Jabal Azzan region south of Aleppo last weekend.
The Pentagon said there is “no US military activity near Homs at this time”.
It is unclear at this time what the explosion is or if anyone was hurt.
The recent incidents come after a coordinated attack by the US, UK and France that saw over 100 missiles launched from US ships and UK Tornado fighter-bombers.
The strike was designed to disable the country’s use of chemical weapons after it allegedly used chlorine against rebels in Douma, eastern Ghouta on April 7.